Association of SNPs in the TLR4 gene (rs4986790, rs4986791) with Susceptibility to Active TB in Iraqi Population

Abstract

The main objective of this work was to assess the potential relation of (rs4986790 as well as rs4986791) SNPs, located at the TLR4 gene, and the susceptibility to developing active tuberculosis (TB). Approximately 78.9% of the samples demonstrated resistance to rifampicin. Testing of the TLR4 rs4986790 variant did not showed any significant differences in genotype frequencies between patients diagnosed with tuberculosis (TB) and the control group. The study revealed notable disparities in the genotypic and allelic frequencies observed between the groups in relation to TLR4 rs4986791. Individuals harboring the TT genotype showed an increased susceptibility to tuberculosis (TB), whereas those carrying the CC or CT genotypes revealed a decreased susceptibility. The results suggest that the TLR4 rs4986790 mutation may not exert a significant influence on the vulnerability to tuberculosis (TB) within this specific community. In spite of that, it had been suggested that the rs4986791 variant may apply a substantial impact on the susceptibility to tuberculosis.